概述

产品名称：Purified Anti-Human CD45 Monoclonal Antibody

描述：CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA), B220, and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

应用范围：FCM

种属反应性：Human

性能

形态：Liquid

存储条件：Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at -20°C or lower. Avoid cycles of freezing and thawing.

存储溶液：0.01M PBS, pH 7.0 with 0.09% NaN3

亚型：Mouse IgG1

应用

应用说明：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Since applications vary, the appropriate dilutions must be determined for individual use.

别名：LCA