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APC Anti-Mouse CD278 Monoclonal Antibody ICOS 17G9 MHR12781-11Cdatasheet

数据表

  • 概述

    APC Anti-Mouse CD278 Monoclonal Antibody

    The 17G9 antibody reacts with the 47-57 kD ICOS protein, also known as inducible costimulatory molecule, and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes and can costimulate T cells and induce proliferation. In addition ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand, B7h/B7RP-1 and B7-H2 is constitutively expressed in B cell areas of secondary lymphoid organs and can be induced in other tissues by LPS. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. ICOS stimulation has been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.

    FCM

    Mouse

    Rat

  • 性能

    liquid

    Keep as concentrated solution. Store at 4°C and protected from prolonged exposure to light. Do not freeze.

    PBS pH 7.2, 0.09% NaN3, 0.2% BSA

    0.2 mg/ml

    17G9

    Rat IgG2b

  • 应用

    Recommended Application: FC

    Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis (The amount of the reagent is suggested to be used ≤ 1.0 µg /10^6 cells in 100 µl). Since applications vary, the appropriate dilutions must be determined for individual use.

    ICOS

  • 图像
    APC Anti-Mouse CD278 Monoclonal Antibody.jpg
    Con A-stimulated (3 days) C57BL/6 splenocytes stained with FITC anti-mouse CD3 and APC anti-mouse CD278