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LE/AF Purified Anti-Mouse CD274 Monoclonal Antibody PD-L1 M12741-14Fdatasheet

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数据表

  • 概述

    LE/AF Purified Anti-Mouse CD274 Monoclonal Antibody

    CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

    FCM

    Mouse

  • 性能

    Liquid

    Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Avoid cycles of freezing and thawing.

    PBS, pH 7.2

    1mg/ml, >95% (by SDS-PAGE)

    Rat IgG2b

  • 应用

    PD-L1