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LE/AF Purified Anti-Human CD28 Monoclonal Antibody
CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.
FCM,IHC,IP,Costim,Activ
Human
Liquid
Keep as concentrated solution.Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Whenever possible avoid freeze/thaw cycles.
PBS, pH 7.0
1mg/ml, >95% (by SDS-PAGE)
Mouse IgG1
This CD28.2 antibody has been reported for use in Flow Cytometric Analysis, Immunohistochemical Staining and Immunoprecipitation. It has also been reported for use in costimulation.
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