概述

产品名称：LE/AF Purified Anti-Human CD28 Monoclonal Antibody

描述：CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.

应用范围：FCM,IHC,IP,Costim,Activ

种属反应性：Human

性能

形态：Liquid

存储条件：Keep as concentrated solution.Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Whenever possible avoid freeze/thaw cycles.

存储溶液：PBS, pH 7.0

纯度：1mg/ml, >95% (by SDS-PAGE)

亚型：Mouse IgG1

应用

应用说明：This CD28.2 antibody has been reported for use in Flow Cytometric Analysis, Immunohistochemical Staining and Immunoprecipitation. It has also been reported for use in costimulation.