概述

产品名称：LE/AF Purified Anti-Human CD279 Monoclonal Antibody

描述：The J116 monoclonal antibody reacts with the human CD279, also known as programmed death-1 (PD-1),a 55 kDa glycoprotein belonging to the CD28 family of the Ig superfamily.PD-1 is expressed predominantly on activated T and B lymphocytes cells and thymocytes, It is induced on activated myeloid cells. PD-1 involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.

应用范围：IHC,FA,IP,WB

种属反应性：Human

性能

形态：Liquid

存储条件：Keep as concentrated solution.Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Whenever possible avoid freeze/thaw cycles.

存储溶液：PBS, pH 7.2

纯度：1mg/ml, >95% (by SDS-PAGE)

亚型：Mouse IgG1

应用

应用说明：This PD-1 antibody has been reported for use in Flow Cytometric Analysis, Functional Assays, IHC，IP and Western blot.

别名：PD-1