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APC Anti-Mouse CD357 Monoclonal Antibody
GITR, Glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18, and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ T regulatory (Treg) cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation, and abrogate the inhibitory functions of CD4+CD25+ Treg cells. In vivo activation GITR causes development of autoimmune diseases and restores the suppressed immune responses.
FCM
Mouse
Rat
liquid
Keep as concentrated solution. Store at 4°C and protected from prolonged exposure to light. Do not freeze.
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
0.2 mg/ml
DTA-1
Rat IgG2b
Recommended Application: FC
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis (The amount of the reagent is suggested to be used ≤ 0.25 µg /10^6 cells in 100 µl). Since applications vary, the appropriate dilutions must be determined for individual use.
GITR
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