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APC Anti-Mouse CD314 Monoclonal Antibody NKG2D HMG2D M13141-11Cdatasheet

数据表

  • 概述

    APC Anti-Mouse CD314 Monoclonal Antibody

    NKG2D is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells, a subset of CD8+ T cells, γ/δ T cells and NK1.1+ T cells, as well as in vitro induced LAK cells. NKG2D serves as a stimulatory immunoreceptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Several molecules have been identified as the ligands for NKG2D, including minor histocompatibility molecule, H60, UL16-binding protein-like transcript 1 (Mult1, and a family of retinoic acid early transcript 1 (Rae1) in mice, MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs) in humans. present in both mice and humans. NKG2D ligands trigger cytokine (IFN-γ, GM-CSF, TNF-α, MIP1β and others) and granzyme release from NK cells.

    FCM

    Mouse

    Hamster

  • 性能

    liquid

    Keep as concentrated solution. Store at 4°C and protected from prolonged exposure to light. Do not freeze.

    PBS pH 7.2, 0.09% NaN3, 0.2% BSA

    0.2 mg/ml

    HMG2D

    Hamster IgG

  • 应用

    Recommended Application: FC

    Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis (The amount of the reagent is suggested to be used ≤ 0.25 µg /10^6 cells in 100 µl). Since applications vary, the appropriate dilutions must be determined for individual use.

    NKG2D

  • 图像
    APC Anti-Mouse CD314 Monoclonal Antibody.jpg
    C57BL/6 splenocytes stained with FITC anti-mouse NK1.1 and APC anti-mouse CD314.