概述

产品名称：FITC Anti-Mouse CD278 Monoclonal Antibody

描述：The 17G9 antibody reacts with the 47-57 kD ICOS protein, also known as inducible costimulatory molecule, and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes and can costimulate T cells and induce proliferation. In addition ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand, B7h/B7RP-1 and B7-H2 is constitutively expressed in B cell areas of secondary lymphoid organs and can be induced in other tissues by LPS. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. ICOS stimulation has been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.

应用范围：FCM

种属反应性：Mouse

免疫原：Rat

性能

形态：liquid

存储条件：Keep as concentrated solution. Store at 4°C and protected from prolonged exposure to light. Do not freeze.

存储溶液：PBS pH 7.2, 0.09% NaN3, 0.2% BSA

纯度：0.5 mg/ml

克隆：17G9

亚型：Rat IgG2b

应用

应用说明：Recommended Application: FC

功能：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis (The amount of the reagent is suggested to be used ≤ 0.5 µg /10^6 cells in 100 µl). Since applications vary, the appropriate dilutions must be determined for individual use.

别名：ICOS

图像

FITC Anti-Mouse CD278 Monoclonal Antibody.jpg

Con A-stimulated (3 days) C57BL/6 splenocytes stained with APC anti-mouse CD3 and FITC anti-mouse CD278.