概述

产品名称：FITC Anti-Mouse CD274 Monoclonal Antibody

描述：CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T lymphocyte proliferation and production of IL-10 and IFN-g, in an IL-2-dependent and a PDCD1-independent manner. Its interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

应用范围：FCM

种属反应性：Mouse

免疫原：Rat

性能

形态：liquid

存储条件：Keep as concentrated solution. Store at 4°C and protected from prolonged exposure to light. Do not freeze.

存储溶液：PBS pH 7.2, 0.09% NaN3, 0.2% BSA

纯度：0.5 mg/ml

克隆：10F.9G2

亚型：Rat IgG2b

应用

应用说明：Recommended Application: FC

功能：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis (The amount of the reagent is suggested to be used ≤ 0.5 µg /10^6 cells in 100 µl). Since applications vary, the appropriate dilutions must be determined for individual use.

别名：PD-L1

图像

FITC Anti-Mouse CD274 Monoclonal Antibody.jpg

C57BL/6 mouse splenocytes stained with FITC anti-mouse CD274