概述

产品名称：LE/AF Purified Anti-Mouse IL-17A Monoclonal Antibody

描述：IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by TH17 cells,a distinct CD4+ T cell lineage. IL-17A stimulates the production of the pro-inflammatory cytokines IL-1β, TNFα, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity . IL-17A is intimately involved in mucosal immunity against bacterial infections and has a putative role in some autoimmune disorders . IL-17A effects appear to be exerted primarily through binding to the IL-17RA.IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the ERK1/2 MAP kinase, PI3K/Akt, p38, and NF-κB pathways . Phosphorylation of some Jaks and Stats has been observed.

应用范围：FCM,Costim,IP,Neut

种属反应性：Mouse

性能

形态：Liquid

存储条件：Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Avoid cycles of freezing and thawing.

存储溶液：PBS, pH 7.2

纯度：1mg/ml, >95% (by SDS-PAGE)

亚型：Mouse IgG1