概述

产品名称：LE/AF Purified Anti-Mouse CD357 Monoclonal Antibody

描述：GITR, glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18,and AITR (in humans).It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Treg cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+CD4+ T reg cells.In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

应用范围：FCM,IP

种属反应性：Mouse

性能

形态：Liquid

存储条件：Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Avoid cycles of freezing and thawing.

存储溶液：PBS, pH 7.2

纯度：1mg/ml, >95% (by SDS-PAGE)

亚型：Rat IgG2b

应用

应用说明：This DTA-1 antibody has been reported for use in Flow Cytometric Analysis, Immunoprecipitation.

别名：GITR