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LE/AF Purified Anti-Mouse CD126(IL-6R) Monoclonal Antibody IL-6R M11261-14Bdatasheet

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数据表

  • 概述

    LE/AF Purified Anti-Mouse CD126(IL-6R) Monoclonal Antibody

    CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. The 15A7 (D7715A7) antibody blocks IL-6/IL-6 receptor interactions

    FCM

    Mouse

  • 性能

    Liquid

    Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Avoid cycles of freezing and thawing.

    PBS, pH 7.2

    1mg/ml, >95% (by SDS-PAGE)

    Rat IgG2b

  • 应用

    This 15A7 antibody has been reported for use in Flow Cytometric Analysis, Immunoprecipitation, Neutralization and Block.

    IL-6R