概述

产品名称：LE/AF Purified Anti-Mouse CD122 Monoclonal Antibody

描述：CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2 Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rβ subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The TM-β1 antibody does inhibit IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

应用范围：FCM,IP, Block,Deplete

种属反应性：Mouse

性能

形态：Liquid

存储条件：Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Avoid cycles of freezing and thawing.

存储溶液：PBS, pH 7.2

纯度：1mg/ml, >95% (by SDS-PAGE)

亚型：Rat IgG2b

应用

应用说明：This TM-β1 antibody has been reported for use in flow cytometric staining. Additional reported applications (for the relevant formats) include: immunoprecipitation1, blocking of IL-2 binding, and NK cell depletion in vivo.

别名：IL-2R b