概述

产品名称：LE/AF Purified Anti-Mouse CD80 Monoclonal Antibody

描述：CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

应用范围：FCM,IHC,IP,Block

种属反应性：Mouse

性能

形态：Liquid

存储条件：Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Avoid cycles of freezing and thawing.

存储溶液：PBS, pH 7.2

纯度：1mg/ml, >95% (by SDS-PAGE)

亚型：Hamster IgG

应用

应用说明：This 16-10A1 antibody has been reported for use in immunoprecipitation, in vitro and in vivo blocking of CTLA-4 Ig to CD80 by blocking costimulation of T cells by activated B cells, and immunohistochemical staining of acetone-fixed frozen sections.

别名：B7-1